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Intimal hyperplasia (IH) is a pathological process of negative vascular remodeling after arterial injury. IH of large or medium arteries generally occurs after injury, ... the elastin was broken/degraded, and obvious inflammatory cell diffuse infiltration was observed (Figure 1D). In 12 of 42 mice, the aneurysmal lesion was accompanied by IH ...
Home Publications Departments. Prevention of intimal hyperplasia after balloon angioplasty and / or stent insertion. or How to mend a broken heart - Just say NO. Mark; Harnek, Jan
By definition, intimal hyperplasia is an abnormal accumulation of cells in the vascular tunica intima; the cell number is increased because of proliferation and/or migration of vascular wall …
The underlying pathophysiology of venous graft disease and late bypass failure includes intimal hyperplasia and subsequent accelerated atherosclerosis. 3 More than 100 …
Aims: Cyclooxygenase-2-derived prostaglandin E2 (PGE2) is thought to promote vascular intimal hyperplasia (IH). It has been reported that the PGE2 receptor EP4 is upregulated in injured vessels, and that EP4 signaling in vascular smooth muscle cells (VSMCs) promotes IH. In contrast, EP4 in endothelial cells has been demonstrated to restrain IH.
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The autologous vein remains the standard conduit for lower extremity and coronary artery bypass grafting despite a 30%-50% 5-y failure rate, primarily attributable to intimal hyperplasia (IH) that develops in the midterm period (3-24 mo) of graft maturation. Our group discovered that externally strengthening vein grafts by cross-linking the adventitial collagen with photochemical tissue ...
Symptomatic recurrent carotid disease occurs in 0.6% to 3% (mean, 1.2%) of patients after carotid endarterectomy.1 Asymptomatic recurrent disease occurs with a much greater frequency, which varies widely (6.7% to 21%), depending on the noninvasive method of detection used.2 These figures represent absolute recurrence rates within variable periods of time after …
Introduction. Intimal hyperplasia (IH) is a buildup of myofibroblast-like cells (neointimal cells) and extracellular matrix (ECM) within the tunica intima, the innermost layer of the vein ().In preaccess veins of patients with CKD, IH manifests as an idiopathic and benign histologic feature that does not compromise blood flow (2 –6).After arteriovenous fistula (AVF) …
The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia Amy L. Lu, a,b Li Yin, PhD, cd Yitao Huang, BS, aZain Husain Islam, Rohan Kanchetty, Campbell Johnston, Kaijie Zhang, MD,a,cd Xiujie Xie, PhD, bKi Ho Park, PhD,a Charles E. Chalfant, PhD, e and Bowen Wang, PhD,a,d …
Intimal hyperplasia after stenting was observed in the animal models (Fig. 1 A–D). By HE staining, we confirmed that SMC proliferation was the main pathological characteristic of intimal hyperplasia in stent, followed by SMC migration into the …
Intimal Hyperplasia. The process of intimal hyperplasia is common to various forms of vascular diseases, such as atherosclerosis, restenosis, and transplant vasculopathy. …
Loss of patency due to intimal hyperplasia remains a leading cause of failure of small diameter synthetic grafts [5]. It has long been hypothesized that intimal hyperplasia develops at the distal anastomosis due to compliance mismatch between the low compliance synthetic graft and the high compliance artery [5]. However, it has been difficult ...
The shifted VSMC migration into the intima and the accumulation of extracellular matrix are hallmarks of intimal hyperplasia . Circulating mitogens, such as angiotensin II and plasmin, may be involved in VSMC proliferation and migration owing to overexposure based on endothelial denudation (Fig. 1). Open in a separate window ...
Low flow promotes instent intimal hyperplasia: Comparison with lumen loss in balloon-injured and uninjured vessels and the effects of the antioxidant pyrrolidine dithiocarbamate. ... [IEL] intact, 1 = IEL broken media compressed but not lacerated, 2 = media lacerated, EEL intact, 3 = EEL lacerated; injury then averaged per segment) [13]. ...
Intimal hyperplasia (IH) is a pathologic process that leads to restenosis after treatment for peripheral arterial disease. Heat shock protein 90 (HSP90) is a molecular chaperone that regulates protein maturation. Activation of HSP90 results in increased cell migration and proliferation. 17‑N‑allylamino‑17‑demethoxygeldanamycin (17‑AAG ...
Variability in intimal hyperplasia in preaccess basilic veins from patients with ESKD. (A–C) Cross-sections of basilic veins collected during first-stage surgery of a two-stage brachiobasilic arteriovenous fistula (AVF). Patient in (A) is a 42-year-old Black with history of hypertension; patient in (B) is a 68-year-old Black ...
Intimal hyperplasia (IH), a crucial histopathological injury, forms the basis of vascular stenosis and thrombogenesis. In addition, it is common in maladies such as stenosis at the anastomosis of arteriovenous fistula and …
Postoperative intimal hyperplasia is the major cause of the vein graft occlusion. It is very important to establish an animal model for the start of research. After my vascular surgery residency in Japan, I started my research work on postoperative intimal hyperplasia at the University of Wisconsin- …
Intimal hyperplasia is a normal adaptive feature of arteries in response to injuries, which include invasive vascular interventions. Its development limits the long-term success of bypass grafts. Various pharmacological agents have been successfully employed in experimental models to reduce the degree of intimal hyperplasia.
The most commonly used procedures to induce arterial injury in mice are carotid artery ligation with cessation of blood flow and mechanically-induced denudation of endothelium in the carotid or the femoral arteries. Both procedures result in neointimal hyperplasia after …
cartilage erosion, synovial hemorrhage scores and intimal hyperplasia in the synovial membrane. 4. 2,3. MSM ... Broken collagen type II fibers. Diseased chondrocyte. Degraded extracellular matrix. In osteoarthritic cartilage the metabolism of chondrocytes get disturbed, causing the slowdown of production of extracellular matrix components and ...
Intimal hyperplasia is a product of vascular smooth muscle cell proliferation, migration through the internal elastic lamina, and deposition of extracellular matrix proteins driven by growth …
Phenotypic shift of vascular smooth muscle cells (VSMCs) plays a key role in intimal hyperplasia, especially in patients with diabetes mellitus (DM). This study aimed to investigate the role of dynamin-related protein 1 (DRP1) in mitochondrial fission-mediated VSMC phenotypic shift and to clarify wh …
We determined whether a novel biodegradable external mesh stent could inhibit medial-intimal hyperplasia by suppressing hemodynamic stress on vein grafts and improve long-term patency. Methods: Twenty-four beagles underwent bilateral femoral interposition grafting using reversed femoral veins. Vein grafts were externally supported by a novel ...
Introduction. Intimal hyperplasia (IH) is a buildup of myofibroblast-like cells (neointimal cells) and extracellular matrix (ECM) within the tunica intima, the innermost layer of …
In coronary arteries the development of intimal hyperplasia can be significantly reduced with site-specific delivery of nitric oxide donor. The pathway for this effect is cGMP dependent.
Despite the many recent technological advances in vascular intervention, intimal hyperplasia (IH) remains an expensive, morbid, and unsolved problem. It is estimated that hyperplastic …
Overall, this work supports the intrinsic link between compliance mismatch and intimal hyperplasia and highlights the utility of this ex vivo organ culture model for rapid screening of small diameter vascular grafts. STATEMENT OF SIGNIFICANCE: We present an ex vivo organ culture model as a means to screen vascular grafts for early markers of ...
Objective: Endoluminal vascular interventions such as angioplasty initiate a sterile inflammatory response resulting from local tissue damage. This response drives the development of intimal hyperplasia (IH) that, in turn, can lead to arterial occlusion. We hypothesized that the ubiquitous nuclear protein and damage-associated molecular pattern molecule, high-mobility group box 1 …